Yes, focusing would be a problem. You might try mounting the lenses to the Contax 645 bellows unit.
Zoerk (
www.zoerk.de) might be able to made an adapter to suit your needs, and may also have a focssing mount you can use. It might be easier to use a high quality enlarging lens -- fitting an L39 screw mount to the 645 via an adapter might be a lot easier.