So if you guys want to consider 16-bit files fine but don't worry about profiles. Get good ones and don't concern yourself with the node or "bit depth".
After you build the profile, you can use either an 8-bit or 16-bit file just like you can with ANY file you print out of Photoshop.
Here is a cut and paste from the initial 5000 review at LL;
"I discovered early on that one actually needs to have different profiles for the regular OS level driver and the special 16 bit driver."
This led me (and others I suppose) to believe the difference Michael was referring to was a bit depth selection at the time of creating the profile. If there is no bit depth to a profile what is the difference he is referring to?