I'm working on a PC so my settings are LZW, Interleaved & IBM PC
Actually, for 16 bit files, LZW will sometimes produce BIGGER files than uncompressed (and other tiff reader can barf on LZW).
I use zip compression with zip on layers as well. At this point in time Mac or PC isn't all that important and for Photoshop neither is the Pixel Order (but Interleaved is more standard). Zip compression can be a bit slower saving and opening but it produces the smalles file size even with 16 bit files.