Are you on Snow Leopard? There are some profile issues with the new OS that might relate to your problem.
I’ve had zero problems on two machines printing targets and then profiles to various Epson’s. This isn’t to say there are no issues. Yesterday I had a conversation with Chris Murphy, he can’t print anything out of CS4 using No Color Management (the data never makes it to the printer). Tried on this end, no issue. He’s also having issues with green’s but again, two machines here worked correctly and identically. I wish we could figure out what is causing this rare problem. I say rare because it only appears to affect a few.
One additional point I would mention is that when printing a target via Lightroom or Photoshop CS3, checking the box in the Epson print driver to turnoff color management disables both the ColorSync and Epson Color Control controls.
Martin, you can’t print targets out of Lightroom as there’s no No Color Management option. And while you could build a profile using Color Controls (instead of the No Color Adjustment in the Epson driver), you’ll sacrifice a lot of color gamut in the resulting profile.