Depends on what printers and driver versions you are using, but generally you set PS to manage color and turn off CM in the driver. If drivers are written correctly for 10.6 and app that use Apples new print path. CM in the driver is automatically turned off when application manages color is selected.
I am using both an Epson 2880 and 3880. There is this: http://www.luminous-landscape.com/tutorials/solving.shtml
The work around is for Epson/CS4/snow leopard, but I am running 10.6.3 and there is a thread here that suggests that the problem may be fixed in the .3 version. Should I just have 2 profiles made per printer, using the work around and the turning off color managment and see which works best?
Is there an image somewhere that I can print out using boths methods and then tell which one is working based on the color?