A basic assumption here is that there are no changes in color-space. I'm aware that changing color-spaces complicates things but I'm trying to keep the question simple.
You are incorrect in stating that there is no change in colour-space as you are changing from the colour-space being used in NX2* to the colour-space of the printer, represented by the printer/paper/ink profile. As such NX2 has to attempt a colour-space change and make an attempt to convert the colours between the mismatched profiles. This conversion is already attempting to make a good match but cannot know which colours are important to you and whether you would prefer a saturation change or a colour change if needed to fit the output profile.
Does NX2 offer different choices for the rendering intent, ie a choice between perceptual matching or relative colourimetric matching? If it does, you should first try the alternative rendering intent. If this isn't possible or doesn't help then you should be looking at local corrections (ie assume that NX2 offers local corrections) to those areas where you wish to make changes, rather than global corrections that are likely to change areas that you are happy with.
* Or the colour-spage of the image - I am not certain which is the case as I do not know how NX2 works. When printing in Photoshop it would be the colour-space of the image, whereas when printing in Lightroom it would be the Melisa RGB colour-space used internally by Lightroom.